Journal
GERIATRICS & GERONTOLOGY INTERNATIONAL
Volume 16, Issue 1, Pages 21-27Publisher
WILEY
DOI: 10.1111/ggi.12428
Keywords
antibody; cytomegalovirus; elderly patients; functional status; hypertension
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Funding
- Public Welfare & Safety Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2011-0020961]
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AimTo evaluate the relationship between human cytomegalovirus (HCMV) antibody status, and hypertension and functional status among elderly Koreans. MethodsPatients aged 65years were prospectively enrolled from March 2011 to February 2012 at a 2000-bed university hospital. We collected data including CD4+ and CD8+ T-lymphocyte count, and functional status by measuring basic activities of daily living and instrumental activities of daily living for all patients. In addition, HCMV immunoglobulinG levels were analyzed using enzyme-linked fluorescent assay. ResultsDuring the study period, 103 patients (51 men), who were admitted for treatment of infections or other diseases, were enrolled. Multivariate analysis showed that body mass index and HCMV immunoglobulinG antibody titers were independent factors associated with hypertension in elderly patients (OR 1.347, 95% CI 1.113-1.630, P=0.002; OR 1.023, 95% CI 1.001-1.047, P=0.042, respectively). In univariate linear correlations, HCMV antibody levels were positively correlated with systolic blood pressure levels (r=0.303, P=0.002), CD8+ T-lymphocyte count (r=0.313, P=0.001) and instrumental activities of daily living scores (r=0.217, P=0.028). In addition, HCMV immunoglobulinG titers were inversely associated with estimated glomerular filtration rate (r=-0.268, P=0.006). These four variables remained independently significant in multivariate correlation analysis. ConclusionThese findings could provide insight into the important role of HCMV in the pathogenesis of essential hypertension and decreased functional status in the elderly. Geriatr Gerontol Int 2016; 16: 21-27.
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