Journal
JOURNAL OF VIROLOGY
Volume 90, Issue 6, Pages 3253-3256Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02582-15
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Funding
- National Natural Science Foundation of China (NSFC) [81290341, 31321001]
- Science and Technology of the People's Republic of China [2014ZX10004001-003, 2013FY113500]
- HHS \ National Institutes of Health (NIH) [NIAID R01AI110964]
- National Research Foundation Singapore (NRF) [NRF2012NRF-CRP001-056]
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We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.
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