4.6 Article

Exosomal Communication Goes Viral

Journal

JOURNAL OF VIROLOGY
Volume 89, Issue 10, Pages 5200-5203

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02470-14

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Funding

  1. Florida Department of Health grant [4BB05]
  2. FSU College of Medicine

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Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses, recent findings suggest that alterations in normal exosome biology may promote the development and progression of cancer. These studies will be discussed in the context of our current knowledge of Epstein-Barr virus (EBV)-modified exosomes.

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