Journal
JOURNAL OF VIROLOGY
Volume 90, Issue 2, Pages 626-629Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01500-15
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Funding
- HHS \ NIH \ National Institute of General Medical Sciences (NIGMS) [P30GM110703]
- American Heart Association (AHA) [14GRNT19970013, 12GRNT11890012]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P30GM110703] Funding Source: NIH RePORTER
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The viral glycoproteins that decorate enveloped viruses play crucial roles in cell entry and in large part dictate the spectrum of cell types that a virus can infect. The identification in human cytomegalovirus (HCMV) of a viral endoplasmic reticulum (ER)resident glycoprotein that regulates the composition of alternative viral envelope glycoprotein complexes raises the intriguing possibility that certain viruses might actively regulate the tropism of progeny virions to improve their fitness or to navigate through the host.
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