Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 14, Pages 7433-7438Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00605-15
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [FOR1202/UR72/2-5]
- Bundesministerium fur Bildung und Forschung (BMBF)
- Excellence Initiative of the German Federal Ministry of Education and Research (GSC-4, Spemann Graduate School)
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CD8(+) T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8(+) T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2(hNTCP) cells that endogenously processed viral antigens and presented them to HBV-specific CD8(+) T cells. This induced cytolytic and noncytolytic CD8(+) T-cell effector functions and reduction of viral loads.
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