4.6 Article

Pan-genotypic Hepatitis C Virus Inhibition by Natural Products Derived from the Wild Egyptian Artichoke

Journal

JOURNAL OF VIROLOGY
Volume 90, Issue 4, Pages 1918-1930

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02030-15

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Funding

  1. FEDER
  2. Spanish Ministry of Economy and Competitiveness [BFU 2013-44629-R, SAF2013-46077-R]
  3. Maria de Maeztu Programme for Units of Excellence in RD [MDM-2014-0370]
  4. ICREA Funding Source: Custom

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Hepatitis C virus (HCV) infection is the leading cause of chronic liver diseases. Water extracts of the leaves of the wild Egyptian artichoke (WEA) [Cynara cardunculus L. var. sylvestris (Lam.) Fiori] have been used for centuries in the Sinai Peninsula to treat hepatitis symptoms. Here we isolated and characterized six compounds from the water extracts of WEA and evaluated their HCV inhibition capacities in vitro. Importantly, two of these compounds, grosheimol and cynaropicrin, inhibited HCV with half-maximal effective concentrations (EC(50)s) in the low micromolar range. They inhibited HCV entry into target cells and were active against both cell-free infection as well as cell-cell transmission. Furthermore, the antiviral activity of both compounds was pan-genotypic as HCV genotypes 1a, 1b, 2b, 3a, 4a, 5a, 6a, and 7a were inhibited. Thus, grosheimol and cynaropicrin are promising candidates for the development of new pan-genotypic entry inhibitors of HCV infection.

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