Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 24, Pages 12513-12517Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01674-15
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Funding
- NIH [R01 AI093580, R01 AI083409]
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Several arenavirus pathogens, such as Lassa and Junin viruses, inhibit macrophage activation, the molecular mechanism of which is unclear. We show that lymphocytic choriomeningitis virus (LCMV) can also inhibit macrophage activation, in contrast to Pichinde and Tacaribe viruses, which are not known to naturally cause human diseases. Using a recombinant Pichinde virus system, we show that the LCMV Z N-terminal domain (NTD) mediates the inhibition of macrophage activation and immune functions.
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