Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 23, Pages 12221-12225Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02382-15
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Funding
- American Heart Association [AHA 15PRE25090135, AHA 14SDG20390009]
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Human cytomegalovirus (HCMV) pUL93 is essential for virus growth, but its precise function in the virus life cycle is unknown. Here, we characterize a UL93 stop mutant virus (UL93st-TB40/E-BAC) to demonstrate that the absence of this protein does not restrict viral gene expression; however, cleavage of viral DNA into unit-length genomes as well as genome packaging is abolished. Thus, pUL93 is required for viral genome cleavage and packaging.
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