Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 8, Pages 4700-4704Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03546-14
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Funding
- German Center of Infection Research (DZIF)-EBOCON grant
- Leibniz Center of Infection
- German Federal Ministry of Health
- Freie und Hansestadt Hamburg
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The development of treatments for Ebola virus disease (EVD) has been hampered by the lack of small-animal models that mimick human disease. Here we show that mice with transplanted human hematopoetic stem cells reproduce features typical of EVD. Infection with Ebola virus was associated with viremia, cell damage, liver steatosis, signs of hemorrhage, and high lethality. Our study provides a small-animal model with human components for the development of EVD therapies.
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