Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 11, Pages 6121-6125Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00430-15
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Funding
- NIH grant [R01AI089728]
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Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.
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