Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 11, Pages 6155-6160Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00256-15
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Funding
- National Institutes of Health/National Center for Research Resources/National Heart, Lung and Blood Institute/National Institute of Allergy and Infectious Diseases [R01 RR025781, RO1 HL117715]
- NIH [T32AI065380-10]
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Simian immunodeficiency virus SIVsab infection is completely controlled in rhesus macaques (RMs) through functional immune responses. We report that in SIVsab-infected RMs, (i) viral replication is controlled to <0 to 3 copies/ml, (ii) about one-third of the virus strains in reservoirs are replication incompetent, and (iii) rebounding virus after CD8(+) cell depletion is replication competent and genetically similar to the original virus stock, suggesting early reservoir seeding. This model permits assessment of strategies aimed at depleting the reservoir without multidrug antiretroviral therapy.
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