Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 7, Pages 4035-4039Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02612-14
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Funding
- National Institute of Allergy and Infectious Diseases, National Institutes of Health [AI067380]
- Ruth L. Kirschstein National Research Service Award under the American Recovery and Reinvestment Act [F32 AI084432-01]
- National Center for Research Resources [5P20RR016480-12]
- National Institute of General Medical Sciences [8 P20 GM103451-12]
- NMSU Genomics Core facility
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To test the hypothesis that RNA interference (RNAi) imposes diversifying selection on RNA virus genomes, we quantified West Nile virus (WNV) quasispecies diversity after passage in Drosophila cells in which RNAi was left intact, depleted, or stimulated against WNV. As predicted, WNV diversity was significantly lower in RNAi-depleted cells and significantly greater in RNAi-stimulated cells relative to that in controls. These findings reveal that an innate immune defense can shape viral population structure.
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