Journal
GENOMICS
Volume 93, Issue 1, Pages 13-16Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2008.07.006
Keywords
Biomarker; Cancer; Gene Expression; High-dimensional data; Proteomics
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With the development of new technologies for assaying biological activity on a global basis in experimental samples, various new -omics signatures have beer, developed to predict disease progression. Such signatures hold the potential to alter the nature of clinical management of human disease. In this article, we describe some necessary statistical considerations needed to take these signatures from the discovery phase to a clinically useful assay. Much of the work discussed is in the area of cancer. (C) 2008 Elsevier Inc. All rights reserved.
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