Journal
GENOMICS
Volume 91, Issue 3, Pages 243-248Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2007.11.002
Keywords
gene expression; genome regulation; gene coexpression; gene clusters; eukaryotes
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Accumulating evidence indicates that gene order in eukaryotic genomes is not completely random and that genes with similar expression levels tend to be clustered within the same genomic neighborhoods. The mechanism behind these gene coexpression clusters is as yet unclear. In this article, plausible biochemical, genetic, evolutionary, and technological determinants of this pattern are briefly reviewed. (C) 2007 Elsevier Inc. All rights reserved.
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