Journal
GENOMICS
Volume 92, Issue 5, Pages 255-264Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2008.07.001
Keywords
Illumina/Solexa; ABI/SOLiD; 454/Roche; Functional genomics; Next-generation sequencing technology; Transcriptome; Epigenome; Deep sequencing; Sequencing by synthesis; Sequencing by ligation
Funding
- National Cancer Institute of Canada
- Genome Canada
- Genome British Columbia
- British Columbia Cancer Foundation
- Natural Sciences and Engineering Research Council of Canada
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A new generation of sequencing technologies, from Illumina/Solexa, ABI/SOLiD, 454/Roche, and Helicos, has provided unprecedented opportunities for high-throughput functional genomic research. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted resequencing, discovery of transcription factor binding sites, and noncoding RNA expression profiling. This review discusses applications of next-generation sequencing technologies in functional genomics research and highlights the transforming potential these technologies offer. (C) 2008 Elsevier Inc. All rights reserved.
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