Journal
GENOME RESEARCH
Volume 24, Issue 4, Pages 570-579Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.156877.113
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Funding
- National Institutes of Health [CA132755, CA130899]
- University of Michigan Cancer Center
- GI Peptide Research Center
- Department of Defense
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H2A. B is a unique histone H2A variant that only exists in mammals. Here we found that H2A. B is ubiquitously expressed in major organs. Genome-wide analysis of H2A. B in mouse ES cells shows that H2A. B is associated with methylated DNA in gene body regions. Moreover, H2A. B-enriched gene loci are actively transcribed. One typical example is that H2A. B is enriched in a set of differentially methylated regions at imprinted loci and facilitates transcription elongation. These results suggest that H2A. B positively regulates transcription elongation by overcoming DNA methylation in the transcribed region. It provides a novel mechanism by which transcription is regulated at DNA hypermethylated regions.
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