Journal
GENOME RESEARCH
Volume 22, Issue 2, Pages 188-195Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.124354.111
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Funding
- Canadian Institutes for Health Research (CIHR) [MOP 86731, MOP 94867, MOP-110949]
- Canadian Cancer Society [CCS20485]
- U.S. Department of Defense (CDMRP) [W81XWH-10-1-0634]
- NIH [R01 DE015965]
- NCI Early Detection Research Network
- Canary Foundation
- U.S. National Institutes of Health [HG004663)]
- Vanier Canada Graduate Scholarship
- Banting Postdoctoral Fellowship
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The genomics era has yielded great advances in the understanding of cancer biology. At the same time, the immense complexity of the cancer genome has been revealed, as well as a striking heterogeneity at the whole-genome (or omics) level that exists between even histologically similar tumors. The vast accrual and public availability of multi-omics databases with associated clinical annotation including tumor histology, patient response, and outcome are a rich resource that has the potential to lead to rapid translation of high-throughput omics to improved overall survival. We focus on the unique advantages of a multidimensional approach to genomic analysis in this new high-throughput omics age and discuss the implications of the changing cancer demographic to translational omics research.
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