Journal
GENOME RESEARCH
Volume 18, Issue 4, Pages 644-652Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.071852.107
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Funding
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES014811] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM070743] Funding Source: NIH RePORTER
- NIEHS NIH HHS [R01 ES014811-01A1, R01 ES014811-02S1, R01 ES014811-04, R01 ES014811-05, R01 ES014811-02, ES14811, R01 ES014811, R01 ES014811-03, R01 ES014811-05S1] Funding Source: Medline
- NIGMS NIH HHS [R01 GM070743, R01 GM070743-04, R01 GM070743-01, GM070743, R01 GM070743-03, R01 GM070743-02, R01 GM070743-05, R01 GM070743-03S1] Funding Source: Medline
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During a decade of proof-of-principle analysis in model organisms, protein networks have been used to further the study of molecular evolution, to gain insight into the robustness of cells to perturbation, and for assignment of new protein functions. Following these analyses, and with the recent rise of protein interaction measurements in mammals, protein networks are increasingly serving as tools to unravel the molecular basis of disease. We review promising applications of protein networks to disease in four major areas: identifying new disease genes; the study of their network properties; identifying disease-related subnetworks; and network-based disease classification. Applications in infectious disease, personalized medicine, and pharmacology are also forthcoming as the available protein network information improves in quality and coverage.
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