Journal
GENOME BIOLOGY AND EVOLUTION
Volume 6, Issue 6, Pages 1366-1374Publisher
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evu102
Keywords
Holstein; Hanwoo; domestication; milk protein; milk production; positive selection
Categories
Funding
- National Livestock Research Institute [PJ008487]
- BioGreen 21 Project of Rural Development Administration, Republic of Korea [PJ00819101]
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Holstein is known to provide higher milk yields than most other cattle breeds, and the dominant position of Holstein today is the result of various selection pressures. Holstein cattle have undergone intensive selection for milk production in recent decades, which has left genome-wide footprints of domestication. To further characterize the bovine genome, we performed whole-genome resequencing analysis of 10 Holstein and 11 Hanwoo cattle to identify regions containing genes as outliers in Holstein, including CSN1S1, CSN2, CSN3, and KIT whose products are likely involved in the yield and proteins of milk and their distinctive black-and-white markings. In addition, genes indicative of positive selection were associated with cardiovascular disease, which is related to simultaneous propagation of genetic defects, also known as inbreeding depression in Holstein.
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