Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 17, Pages 9137-9141Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01293-15
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Funding
- National Health and Medical Research Council (NHMRC), Australia
- NHMRC senior principal research fellowship
- Cancer Research UK [15032] Funding Source: researchfish
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Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBV-specific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.
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