Journal
GENETICS IN MEDICINE
Volume 21, Issue 4, Pages 939-947Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41436-018-0282-3
Keywords
MODY; GCK; prevalence; type 2 diabetes; prediabetes
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Funding
- Beijing Science and Technology Committee Fund [Z141100007414002, D131100005313008]
- National Key Research and Development Program [2016YFC1304901]
- National High-Technology Research and Development Program of China [2012AA02A509]
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Purpose: To estimate the prevalence of glucokinase variant-induced diabetes (GCK-DM) in a general population and to establish a clinical strategy for identifying GCK-DM from type 2 diabetes (T2DM). Methods: A population-based study of diabetes in a rural region of Beijing, China, was conducted using two-stage stratified random cluster sampling. The glucokinase exons were sequenced in patients with diabetes. Results: A total of 3345 subjects, including 545 patients with diabetes, participated in this study. Seven patients with GCK-DM were identified. The estimated prevalence rates of GCK-DM were 0.21% and 1.3% in the whole population and the diabetic patients, respectively. In the newly diagnosed diabetic patients (New-DM), a triglyceride cutoff <= 1.43 mmol/L (126.55 mg/dl) could discriminate GCK-DM from T2DM with 100% sensitivity and 68.4% specificity. Its effectiveness was confirmed in an additional 134 early-onset young patients with T2DM and mild hyperglycemia. A clinical criterion based on triglyceride and mild hyperglycemia could differentiate GCK-DM from T2DM in New-DM and was shown to be effective in identifying GCK-DM from 559 early-onset young patients with T2DM in the hospital. Conclusions: The prevalence of GCK-DM is approximately 1.3% in the Chinese population with diabetes, and the new clinical screening strategy is helpful for identifying GCK-DM.
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