Journal
GENETICS IN MEDICINE
Volume 16, Issue 4, Pages 329-337Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/gim.2013.143
Keywords
birth defects; data collection; epidemiologic methods; ethnic groups; risk factors
Categories
Funding
- NIEHS NIH HHS [P30 ES005605] Funding Source: Medline
- NCBDD CDC HHS [U01 DD001035] Funding Source: Medline
- Intramural CDC HHS [CC999999] Funding Source: Medline
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Purpose: As epidemiological studies expand to examine gene environment interaction effects, it is important to identify factors associated with participation in genetic studies. The National Birth Defects Prevention Study is a multisite case-control study designed to investigate environmental and genetic risk factors for major birth defects. The National Birth Defects Prevention Study includes maternal telephone interviews and mailed buccal cell self-collection kits. Because subjects can participate in the interview, independent of buccal cell collection, detailed analysis of factors associated with participation in buccal cell collection was possible. Methods: Multivariable logistic regression models were used to identify the factors associated with participation in the genetic component of the study. Results: Buccal cell participation rates varied by race/ethnicity (non-Hispanic whites, 66.9%; Hispanics, 60.4%; and non-Hispanic blacks, 47.3%) and study site (50.2-74.2%). Additional monetary incentive following return of buccal cell kit and shorter interval between infant's estimated date of delivery and interview were associated with increased participation across all racial/ethnic groups. Higher education and delivering an infant with a birth defect were associated with increased participation among non-Hispanic whites and Hispanics. Conclusion: Factors associated with participation varied by race/ethnicity. Improved understanding of factors associated with participation may facilitate strategies to increase participation, thereby improving generalizability of study findings.
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