Journal
GENETICS IN MEDICINE
Volume 10, Issue 4, Pages 231-239Publisher
NATURE PUBLISHING GROUP
DOI: 10.1097/GIM.0b013e31816b64dc
Keywords
Alzheimer; dementia; amyloid; neurogenetics
Categories
Funding
- NATIONAL INSTITUTE ON AGING [P50AG005136] Funding Source: NIH RePORTER
- NIA NIH HHS [P50 AG005136-229007, P50 AG005136-25, P50 AG005136-140003, P50 AG 005136-22, P50 AG005136] Funding Source: Medline
Ask authors/readers for more resources
Alzheimer disease is the most common cause of dementia and represents a major public health problem. The neuropathologic findings of amyloid-beta plaques and tau containing neurofibrillary tangles represent important molecular clues to the underlying pathogenesis. Genetic factors are well recognized, but complicated. Three rare forms of autosomal-dominant early-onset familial Alzheimer disease have been identified and are associated with mutations in amyloid precursor protein, presenilin 1, and presenilin 2 genes. The more common late-onset form of Alzheimer disease is assumed to be polygenic/multifactorial. However, thus far the only clearly identified genetic risk factor for Alzheimer disease is Apo lipoprotein E. The epsilon 4 allele of Apo lipoprotein E influences age at onset of Alzheimer disease, but is neither necessary nor Sufficient for the disease. The search continues for the discovery of additional genetic influences.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available