Journal
JOURNAL OF VIROLOGY
Volume 90, Issue 4, Pages 2119-2126Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01975-15
Keywords
-
Categories
Funding
- HHS \ NIH \ National Institute of Allergy and Infectious Diseases (NIAID) [AI 084787, AI 112447]
- NIH [OD011106, OD011104]
Ask authors/readers for more resources
Nef-specific CD8(+) T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B(star)017:01-restricted Nef(165-173)IW9 epitope revealed highly restricted evolution. A common acute escape variant, T170I, unexpectedly and uniquely degraded Nef's major histocompatibility complex class I (MHC-I) downregulatory capacity, rendering the virus more vulnerable to CD8TL targeting other epitopes. These data aid in a mechanistic understanding of Nef functions and suggest means of immunity-mediated control of lentivirus replication.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available