Journal
GENETICS AND MOLECULAR RESEARCH
Volume 13, Issue 1, Pages 1383-1394Publisher
FUNPEC-EDITORA
DOI: 10.4238/2014.February.28.11
Keywords
IL-4; Promoter; Polymorphisms; Meta-analysis; Asthma
Funding
- Education Department Project of Hunnan Province [12C0523]
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This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly associated with asthma; however, significant associations were found only in the European population. In addition, the TT+ CT genotype was significantly associated with asthma in adults and no significant association was found in asthma status subgroup analyses. This meta-analysis showed that IL-4 C-589T and C-33T were associated with asthma in Europeans. To further confirm correlations between polymorphisms of the IL-4 promoter with asthma susceptibility, studies involving a larger number of patients worldwide are necessary.
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