Journal
JOURNAL OF VIROLOGY
Volume 89, Issue 8, Pages 4676-4680Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00169-15
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Funding
- U.K. Medical Research Council
- European Commission [PIEF-GA-2009-237501]
- King's alumni community
- Wellcome Trust
- Department of Health via a National Institute for Health Research comprehensive Biomedical Research Centre
- St. Thomas' NHS Foundation Trust
- King's College London
- King's College Hospital NHS Foundation Trust
- Medical Research Council [G1001081, G1000196, MR/M001199/1] Funding Source: researchfish
- MRC [G1001081, G1000196, MR/M001199/1] Funding Source: UKRI
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We have employed molecular genetic approaches to understand the domain organization of the HIV-1 resistance factor myxovirus resistance 2 ( MX2). First, we describe an essential triple-arginine motif in the amino-terminal domain. Second, we demonstrate that this 91-residue domain mediates antiviral activity when appended to heterologous proteins, and we provide genetic evidence that protein oligomerization is required for MX2 function. These insights will facilitate future work aiming to elucidate MX2's mechanism of action.
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