Journal
GENETICS AND MOLECULAR RESEARCH
Volume 11, Issue 1, Pages 147-152Publisher
FUNPEC-EDITORA
DOI: 10.4238/2012.January.27.1
Keywords
Biomarker; Circulation; Gene expression; Ischemic stroke; MicroRNA-145; Postnatal neovascularization
Funding
- University Malaya (UMRG) [FS192/2008B]
- University Malaya (PPP) [PS385/2009B]
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Cerebral ischemia or ischemic stroke is mainly attributed to vascular and circulation disorders. Among protein biomarkers, RNA profiles have also been identified as markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as marker and modulator of vascular smooth muscle cell phenotype; however, expression levels in ischemic stroke had not been investigated. Employing real-time quantitative PCR, we examined the expression profile of circulatory microRNA-145 in healthy control subjects (N = 14) and ischemic stroke patients (N = 32). Circulatory microRNA-145 expression was significantly higher in ischemic stroke patients than in control subjects. This demonstrates that hemostatic mechanisms are affected by ischemic stroke. We conclude that circulating microRNA-145 has potential as a biomarker for ischemic stroke.
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