Journal
GENETICS AND MOLECULAR RESEARCH
Volume 11, Issue 4, Pages 3642-3648Publisher
FUNPEC-EDITORA
DOI: 10.4238/2012.October.4.11
Keywords
ODF3; ODF4; Cloning; Alternative splicing; Cancer-testis gene
Funding
- Tehran University of Medical Sciences
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The outer dense fiber (ODF) genes encode proteins that co-assemble along the axoneme of the sperm tail. Recently, it was demonstrated that some ODF genes are aberrantly expressed in tumors, including prostate adenocarcinoma, basal cell carcinoma, and chronic myeloid lymphoma. We cloned ODF3 and ODF4 cDNA from the testis of a patient suffering from prostate adenocarcinoma and found two alternative splice variants of these genes.
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