Journal
GENETICS AND MOLECULAR RESEARCH
Volume 9, Issue 4, Pages 2166-2175Publisher
FUNPEC-EDITORA
DOI: 10.4238/vol9-4gmr973
Keywords
Essential hypertension; Gene polymorphisms; Haptoglobin; Manganese superoxide dismutase
Funding
- University of Brasilia (UnB)
- National Council for Technological and Scientific Development (CNPq)
- Scientific and Technological Enterprises Foundation (FINATEC)
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Essential hypertension is a complex and multifactorial trait; genetic and environmental factors interact to produce the final phenotype. Studies have demonstrated association of hypertension with varied gene polymorphisms. However, demonstration of common genetic causes in the general population remains elusive. We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasilia. Although ACE has been reported to be one of the main polymorphisms associated with hypertension, we found no association with ACE's specific genotypes. However, a possible association with Hp1-1 and MnSOD Val/Ala genotypes suggests that, at least for the Brazilian population, polymorphisms related to oxidative stress should be more deeply investigated.
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