Journal
GENETICS AND MOLECULAR BIOLOGY
Volume 35, Issue 3, Pages 701-708Publisher
SOC BRASIL GENETICA
DOI: 10.1590/S1415-47572012005000045
Keywords
graph clustering; pathway crosstalk; protein-protein interaction network
Funding
- Anhui Provincial Natural Science Funding for Key Projects [KJ2010A171]
- Medicine Research Projects Schedule of the Province Health Bureau [09C157]
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Gastric cancer is one of the most common and lethal cancers worldwide. However, despite its clinical importance, the regulatory mechanisms involved in the aggressiveness of this cancer are still poorly understood. A better understanding of the biology, genetics and molecular mechanisms of gastric cancer would be useful in developing novel targeted approaches for treating this disease. In this study we used protein-protein interaction networks and cluster analysis to comprehensively investigate the cellular pathways involved in gastric cancer. A primary immunodeficiency pathway, focal adhesion, ECM-receptor interactions and the metabolism of xenobiotics by cytochrome P450 were identified as four important pathways associated with the progression of gastric cancer. The genes in these pathways, e. g., ZAP70, IGLL1, CD79A, COL6A3, COL3A1, COL1A1, CYP2C18 and CYP2C9, may be considered as potential therapeutic targets for gastric cancer.
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