4.4 Article

The Aurora B Kinase Promotes Inner and Outer Kinetochore Interactions in Budding Yeast

Journal

GENETICS
Volume 194, Issue 3, Pages 785-+

Publisher

GENETICS SOC AM
DOI: 10.1534/genetics.113.150839

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Funding

  1. National Institutes of Health [GM078079, GM064386]

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The kinetochore is the macromolecular protein complex that mediates chromosome segregation. The Dsn1 component is crucial for kinetochore assembly and is phosphorylated by the Aurora B kinase. We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast.

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