Journal
GENETICS
Volume 194, Issue 4, Pages 1029-+Publisher
GENETICS SOC AM
DOI: 10.1534/genetics.113.152710
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Funding
- University of Wisconsin
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health [R00 NS072252, R00 NS060985]
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We have adapted a bacterial CRISPR RNA/Cas9 system to precisely engineer the Drosophila genome and report that Cas9-mediated genomic modifications are efficiently transmitted through the germline. This RNA-guided Cas9 system can be rapidly programmed to generate targeted alleles for probing gene function in Drosophila.
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