Journal
GENETICS
Volume 192, Issue 3, Pages 1123-+Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.112.143107
Keywords
-
Categories
Funding
- National Science Foundation [MCB0948512]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0948512] Funding Source: National Science Foundation
Ask authors/readers for more resources
Quantitative trait loci (QTL) with small effects on phenotypic variation can be difficult to detect and analyze. Because of this a large fraction of the genetic architecture of many complex traits is not well understood. Here we use sporulation efficiency in Saccharomyces cerevisiae as a model complex trait to identify and study small-effect QTL. In crosses where the large-effect quantitative trait nucleotides (QTN) have been genetically fixed we identify small-effect QTL that explain approximately half of the remaining variation not explained by the major effects. We find that small-effect QTL are often physically linked to large-effect QTL and that there are extensive genetic interactions between small-and large-effect QTL. A more complete understanding of quantitative traits will require a better understanding of the numbers, effect sizes, and genetic interactions of small-effect QTL.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available