Journal
GENETICS
Volume 189, Issue 3, Pages 705-736Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.111.127019
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Funding
- NIGMS NIH HHS [R01 GM026079, R01 GM075114, R01 GM053451] Funding Source: Medline
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Here we review recent advances in understanding the regulation of mRNA synthesis in Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been conserved in all eukaryotes, and budding yeast has been at the forefront in the discovery and dissection of these conserved mechanisms. Topics covered include upstream activation sequence and promoter structure, transcription factor classification, and examples of regulated transcription factor activity. We also examine advances in understanding the RNA polymerase II transcription machinery, conserved coactivator complexes, transcription activation domains, and the cooperation of these factors in gene regulatory mechanisms.
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