4.4 Article

Extended Linkage Disequilibrium in Noncoding Regions in a Conifer, Cryptomeria japonica

Journal

GENETICS
Volume 190, Issue 3, Pages 1145-U372

Publisher

GENETICS SOC AM
DOI: 10.1534/genetics.111.136697

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Funding

  1. Program for Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry
  2. Japan Society for the Promotion of Science [22370083]
  3. Grants-in-Aid for Scientific Research [22370083] Funding Source: KAKEN

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We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55 x 10(-5) and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies.

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