Journal
GENETICS
Volume 186, Issue 2, Pages 757-U476Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.110.120717
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Funding
- National Science Foundation [DBI 0923827, MCB 0209818, DBI 0820831]
- University of Minnesota
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0726267] Funding Source: National Science Foundation
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Engineered nucleases that cleave specific DNA sequences in vivo are valuable reagents for targeted mutagenesis. Here we report a new class of sequence-specific nucleases created by fusing transcription activator-like effectors (TALEs) to the catalytic domain of the FokI endonuclease. Both native and custom TALE-nuclease fusions direct DNA double-strand breaks to specific, targeted sites.
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