4.4 Article

Condensins Promote Coorientation of Sister Chromatids During Meiosis I in Budding Yeast

Journal

GENETICS
Volume 185, Issue 1, Pages 55-U104

Publisher

GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.110.115139

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Funding

  1. National Science Foundation [NSF-MCB0718384]
  2. National Institutes of Health [GM62207]
  3. Div Of Molecular and Cellular Bioscience
  4. Direct For Biological Sciences [0718384] Funding Source: National Science Foundation

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The condensin complex is a key determinant of higher-ordered chromosome structure. We show here that the complex is also important for the correct alignment of chromosomes on the meiosis I spindle. Unlike during mitosis and meiosis II, when sister chromatids attach to microtubules emanating from opposite spindle poles (biorientation), accurate meiosis I chromosome segregation requires that sister chromatids attach to microtubules emanating from the same spindle pole (coorientation). The monopolin complex, consisting of Lrs4, Csm1, and the meiosis-specific component Mam1, brings about meiosis I coorientation. We find that in the absence of functional condensin complexes, a fraction of sister kinetochores biorient on the meiosis I spindle and association of the monopolin complex subunit Mam1 with kinetochores is decreased. Our studies uncover a new locus-specific effect of the condensin complex.

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