Journal
GENETICS
Volume 183, Issue 4, Pages 1591-1595Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.109.109041
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Funding
- National Institutes of Health [GM064386]
- National Institute of General Medical Sciences [PM50 GM076547]
- Leukemia and Lymphoma Society
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Phosphorylation of the Ndc80 kinetochore protein by the Ipl1/Aurora B kinase reduces its microtubule binding activity in vitro. We found that kinetochore-bound Ndc80 is phosphorylated on Ipl1 sites in vivo, but this phosphorylation is not essential. Instead, we show that additional Ipl1 targets contribute to segregation and the spindle checkpoint.
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