Journal
GENETICS
Volume 183, Issue 1, Pages 131-148Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.109.106203
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Funding
- National Institutes of Health [GM078068]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM078068] Funding Source: NIH RePORTER
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Chromatin insulators separate active front repressed chromatin domains. In yeast the RNA pol III transcription machinery bound to tRNA genes function with histone acetylases and chromatin remodelers to restrict the spread of heterochromatin. Our results collectively demonstrate that: binding of TFIIIC is necessary for insulation but binding of TFIIIB along with TFIIIC likely improves the probability of complex formation at an insulator. Insulation by this transcription factor occurs in the absence of RNA polymerase III or polymerase II but requires specific histone acetylases and chromatin remodelers. This analysis identifies a minimal set of factors required for insulation.
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