Journal
GENETICS
Volume 184, Issue 2, Pages 517-U292Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.109.111161
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Funding
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- U.S. National Science Foundation
- U.S. National Institutes of Health
- Graduate University for Advanced Studies
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Interlocus gene conversion can homogenize DNA sequences of duplicated regions with high homology. Such nonvertical events sometimes cause a misleading evolutionary interpretation of data when the effect of gene conversion is ignored. To avoid this problem, it is crucial to test the data for the presence of gene conversion. Here, we performed extensive simulations to compare four major methods to detect gene conversion. One might expect that the power increases with increase of the gene conversion rate. However, we found this is true for only two methods. For the other two, limited power is expected when gene conversion is too frequent. We suggest using multiple methods to minimize the chance of missing the footprint of gene conversion.
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