Journal
GENETICS
Volume 182, Issue 3, Pages 923-926Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.109.101741
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Funding
- Foundation for Science, Research and Technology (New Zealand)
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beta-Carotene biochemistry is a fundamental process in mammalian biology. Aberrations either through malnutrition or potentially through genetic variation may lead to vitamin A deficiency, which is a substantial public health burden. In addition, understanding the genetic regulation of this process may enable bovine improvement. While many bovine QTL have been reported, few of the causative genes and mutations have been identified. We discovered a QTL for milk beta-carotene and subsequently identified a premature stop codon in bovine beta-carotene oxygenase 2 (BCO2), which also affects serum beta-carotene content. The BCO2 enzyme is thereby identified as a key regulator of P-carotene metabolism.
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