Journal
GENETICS
Volume 179, Issue 1, Pages 193-197Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.107.085936
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Funding
- Natural Environment Research Council [pml010002] Funding Source: researchfish
- NERC [pml010002] Funding Source: UKRI
- Wellcome Trust Funding Source: Medline
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The evolution of specific cell signaling and adhesion domains may have played an important role in the transition to a multicellular existence in the metazoans. Genomic analysis indicates that several signaling domains predominately found in animals are also present in the unicellular green alga, Chlamydomonas reinhardtii. A large group of proteins is present, containing scavenger receptor cysteine-rich (SRCR) and C-type lectin domains, which function in ligand binding and play key roles in the innate immune system of animals. Chlamydomonas also contains a large family of putative tyrosine kinases, suggesting an important role for phosphotyrosine signaling in the green algae. These important signaling domains may therefore be widespread among eukaryotes and most probably evolved in ancestral eukaryotes before the divergence of the Opisthokonts (the animal and fungal lineage).
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