Journal
GENETICS
Volume 178, Issue 1, Pages 67-82Publisher
GENETICS
DOI: 10.1534/genetics.107.071506
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Funding
- NIGMS NIH HHS [R01 GM043987, P50 GM068763, GM43987, R37 GM043987] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM068763, R37GM043987, R01GM043987] Funding Source: NIH RePORTER
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Although mutation rates are a key determinant of the rate of evolution they are difficult to measure precisely and global mutations rates mutations per genome per generation) are often extrapolated from the per-base-pair Mutation rate assuming that mutation rate is uniform across the genome. Using budding yeast, we describe all improved method for the accurate calculation of mutation rates based on the fluctuation assay. Our analysis suggests that. the per-base-pair mutation rates at two genes differ significantly (3.80 X 10(-10)) at URA3 and 6.44 X 10(-10)) at CAN1) and we propose a definition for the effective target size of genes (the probability that it mutation inactivates the gene) that acknowledges that the initiation rate is nonuniform across the genome.
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