Journal
GENETICS
Volume 180, Issue 1, Pages 673-679Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.108.089698
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
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Excision of a Mos1 transposon in the germline of Caenorhabditis elegans generates a double-strand break In the chromosome.,We demonstrate that breaks are most prominently repaired by gene conversion from the homolog, but also rarely, by nonhomologous end-joining. In some cases, gene, conversion events are resolved by crossing over. Surprisingly, expression of the transposase using all intestine-specific promoter can induce repair, raising the possibility that activation of transposase expression in somatic cells can lead to transposition of Mos1 in the germline..
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