Journal
GENETICA
Volume 141, Issue 7-9, Pages 311-318Publisher
SPRINGER
DOI: 10.1007/s10709-013-9730-9
Keywords
Gallus gallus; 5' UTR length; Gene expression pattern; Selection
Categories
Funding
- Science and Technology Program of Jiangxi Education Department, China [GJJ12658]
- Jiangxi provincial natural science fund project, China [2010GZN0021]
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The chicken (Gallus gallus) is an important model organism that bridges the evolutionary gap between mammals and non-amniote vertebrates. Here, we carried out a systematic study of the relationship between 5' UTR length and gene expression pattern in the chicken genome. We found that gene 5' UTRs lengths show a negative correlation with gene expression levels and gene expression breadths significantly. The relevance of 5' UTR length to expression pattern can not be a consequence of transcription-associated mutations. We also found that gene 5' UTR length shows a weakly positive correlation with gene tissue specificity. Another intriguing finding is that genes with 5' UTR length < 30 bp have highest expression level, highest expression breadth, and lowest tissue specificity in chicken. We argued that selection is likely involved in shaping 5' UTR length in the chicken genome.
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