Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 77, Issue 11, Pages 1479-1484Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.15-0197
Keywords
Bisphenol A; Bisphenol AF; Bisphenol F; UDP glucuronosyl transferase (UGT)
Categories
Funding
- Ministry of Health, Labour and Welfare, Japan [H23-Kagaku-004]
- Feasibility Study among Fundamental Studies under the framework of EXTEND (Extended Tasks on Endocrine Disruption) - Ministry of the Environment, Japan
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Bisphenol A (BPA) is a widely used industrial chemical that disrupts endocrine function. BPA is an endocrine disrupting chemical (EDC) that has been demonstrated to affect reproductive organ development, brain development, metabolic disease and post-natal behavior. Accordingly, Bisphenol analogs, Bisphenol F (BPF, bis (4-hydroxyphenyl) methane) and Bisphenol AF (BPAF, 4,4-hexafluoroisopropylidene) diphenol) are used as replacements for BPA. BPA is mainly metabolized by UDP-glucuronosyltransferase (UGT), UGT2B1, but this effective metabolizing system is weak in the fetus. In the present study, we demonstrated that hepatic UGT activity toward BPAF was very weak, in comparison with BPA and BPF, in the fetus, pups and dams. Conversely, hepatic UGT activity toward BPF was very weak in the fetus and newborn pups, and was increased to the same level as BPA post-partum. In conclusion, BPAF possibly tends to accumulate in the fetus, because of weak metabolism during the perinatal period, suggesting that the metabolism of individual Bisphenol analogs requires assessment to properly gauge their risks.
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