Journal
GENESIS
Volume 57, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/dvg.23248
Keywords
bone initiation; gene regulation; skull bone; supraorbital arch mesenchyme
Categories
Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [T32 AR-007505]
- National Institutes of Health
- National Institute of Dental and Craniofacial Research [R01 DE-01870]
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The skull bones must grow in a coordinated, three-dimensional manner to coalesce and form the head and face. Mammalian skull bones have a dual embryonic origin from cranial neural crest cells (CNCC) and paraxial mesoderm (PM) and ossify through intramembranous ossification. The calvarial bones, the bones of the cranium which cover the brain, are derived from the supraorbital arch (SOA) region mesenchyme. The SOA is the site of frontal and parietal bone morphogenesis and primary center of ossification. The objective of this review is to frame our current in vivo understanding of the morphogenesis of the calvarial bones and the gene networks regulating calvarial bone initiation in the SOA mesenchyme.
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