Journal
GENESIS
Volume 53, Issue 1, Pages 34-47Publisher
WILEY
DOI: 10.1002/dvg.22824
Keywords
metamorphosis; gene network; metamorphic mutants; signaling pathways; tail regression; apoptosis; Ciona intestinalis; Boltenia villosa; Herdmania curvata
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Funding
- Emergence-UPMC Research Program
- Andre Picard Network
- Japan Society for the Promotion of Science (JSPS)
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Toray Science and Technology Grant
- National Bioresource Project
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Embryonic and postembryonic development in ascidians have been studied for over a century, but it is only in the last 10 years that the complex molecular network involved in coordinating postlarval development and metamorphosis has started to emerge. In most ascidians, the transition from the larval to the sessile juvenile/adult stage, or metamorphosis, requires a combination of environmental and endogenous signals and is characterized by coordinated global morphogenetic changes that are initiated by the adhesion of the larvae. Cloney was the first to describe cellular events of ascidians' metamorphosis in 1978 and only recently elements of the molecular regulation of this crucial developmental step have been revealed. This review aims to present a thorough view of this crucial developmental step by combining recent molecular data to the already established cellular events. genesis 53:34-47, 2015. (c) 2014 Wiley Periodicals, Inc.
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