Journal
GENESIS
Volume 52, Issue 3, Pages 279-286Publisher
WILEY
DOI: 10.1002/dvg.22737
Keywords
germ line; sea star; primordial germ cells; sea urchin; starfish
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Funding
- NSF [IOS-1120972]
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Nanos is an essential factor of germ line success in all animals tested. This gene encodes a Zn-finger RNA-binding protein that in complex with its partner pumilio binds to and changes the fate of several known transcripts. We summarize here the documented functions of Nanos in several key organisms, and then emphasize echinoderms as a working model for how nanos expression is regulated. Nanos presence outside of the target cells is often detrimental to the animal, and in sea urchins, nanos expression appears to be regulated at every step of transcription, and post-transcriptional activity, making this gene product exciting, every which way. genesis 52:279-286. (c) 2013 Wiley Periodicals, Inc.
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