Journal
JOURNAL OF VETERINARY MEDICAL SCIENCE
Volume 77, Issue 11, Pages 1485-1487Publisher
JAPAN SOC VET SCI
DOI: 10.1292/jvms.15-0213
Keywords
cat; cell tropism; cross-species transmission; feline morbillivirus; host range
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Funding
- Japan Society for the Promotion of Science
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Feline morbillivirus (FmoPV) is an emerging virus in ats, which is associated with tubulointerstitial nephritis. To study the in vitro host range of FmoPV, we inoculated FmoPV strain SS1 to 32 cell lines originated from 13 species and cultured for 2 weeks, followed by RNA extraction and reverse-transcription-polymerase chain reaction for FmoPV detection. As a result, only cell lines derived from cats and African green monkeys were susceptible to FmoPV. FmoPV infects diverse feline cell lines: epithelial, fibroblastic, lymphoid and glial cells. These results indicate that the receptor (s) for FmoPV are ubiquitously expressed in cats. No infectivity of FmoPV was observed in human cell lines, which suggests least threatening of cross-speciesb transmission of FmoPV
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